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In vivo research demonstrate anatomically selective neurochemical results of modafinil on monoaminergic devices (de Saint Hilaire et al 2001; Ferraro et al 2002), and, notably, whilst modafinil improves TMN fos expression (Scammell et al 2000) and HAergic tone it's not able to exert this impact when administered instantly in to the TMN (Ishizuka et